Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Cognitively impaired individuals had more longitudinal synapse loss in the medial temporal lobe, and increased tau burden in the widespread neocortex than healthy controls. The longitudinal change of synaptic density was negatively associated with the longitudinal change of tau burden, and positively associated with longitudinal cognitive decline. Plasma glial fibrillary acidic protein (GFAP) mediates the relationship between longitudinal tau deposition and longitudinal synaptic loss. Tau burden, plasma phosphorylated tau181, and GFAP could predict longitudinal synaptic loss and cognitive decline.
Authors
- Xiaoxie Mao
- Yiyun Huang (ORCID: https://orcid.org/0000-0002-6757-3220)
- Tengfei Guo (ORCID: https://orcid.org/0000-0003-2982-0865)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-9887-5512)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Ruiqing Ni (ORCID: https://orcid.org/0000-0002-0793-2113)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Binyin Li (ORCID: https://orcid.org/0000-0003-1953-382X)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Zhiwen You
- Qi Huang (ORCID: https://orcid.org/0000-0002-9425-6618)
- Xing Chen (ORCID: https://orcid.org/0000-0002-3058-7370)
- Yihui Guan (ORCID: https://orcid.org/0000-0002-2946-4293)
- Kun He (ORCID: https://orcid.org/0000-0002-6969-3488)
- Jie Wang (ORCID: https://orcid.org/0000-0003-4338-2873)
Institutions
- Shanghai Jiao Tong University (CN)
- University of Zurich (CH)
- Fudan University (CN)
- University Hospital of Bern (CH)
- Ruijin Hospital (CN)
- Yale University (US)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Shenzhen Bay Laboratory (CN)
- Munich Cluster for Systems Neurology (DE)
- Shanghai East Hospital (CN)
- Huashan Hospital (CN)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70333
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Fudan University
- Huashan Hospital