A Novel Flavonoid Derivative of Icariside II (YS-10) Improves Erectile Dysfunction in a Diabetic Rat Model by Inhibiting Ferroptosis via Activation of the Nrf2/HO-1/GPX4 Pathway
YS-10 improves erectile function in diabetic rats by reducing oxidative stress and inhibiting ferroptosis via activation of the Nrf2/HO-1/GPX4 pathway. At 2.5 mg/kg/day, YS-10 was effective, well-tolerated, and showed efficacy comparable to ICA II. These findings support its potential as a promising candidate for diabetes-related erectile dysfunction therapy.
Authors
- Zhitao Wei (ORCID: https://orcid.org/0000-0002-1285-9328)
- W.S. Wang
- Guan-Nan Liu
- Yong Yang (ORCID: https://orcid.org/0000-0002-2907-3030)
- Hongwei Li (ORCID: https://orcid.org/0000-0002-1762-1327)
- Yang Liu
- Juntao Sun (ORCID: https://orcid.org/0009-0008-6987-9902)
- Yongde Xu (ORCID: https://orcid.org/0000-0002-4298-7662)
- Yarong Zha
- J. Yao
- Chen-li Pan
- Yueyue Zang
Institutions
- Capital Medical University (CN)
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s518992
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87