A palladium-catalyzed borylative cyclization cascade reaction of 1,7-enynes: access to functionalized cyclohexanes

This study describes a palladium-catalyzed borylative cyclization of 1,7-enynes, featuring mild reaction conditions, moderate to high yields (up to 87%), and excellent regioselectivity for synthesizing diverse functionalized cyclohexanes. The reaction exhibits good tolerance toward various substituents on both alkene and alkyne moieties-including internal alkenes and alkyne-bound aromatic groups, which were previously poorly compatible in related approaches-thereby highlighting the method's potential utility.