Fungicidal Activity of Novel Synthesized 2-(N-Aryloxy Acetyl)-5-(2'-Hydroxy Phenyl)-1, 3, 4-Oxadiazole

After a novel set of 2-(N-aryloxy acetyl)-5-(2'-hydroxy phenyl)-1,3,4-oxadiazole derivatives were created, their fungicidal ability was evaluated. A mild condensation reaction of salicylic acid hydrazide with various aryloxyacetic acid chlorides produced the necessary heterocyclic molecules. The compounds' in vitro antifungal efficacy against a panel of phytopathogenic fungi, including Aspergillus niger, Rhizoctonia solani, and Fusarium oxysporum, was evaluated using the poisoned food technique. Numerous substances had significant inhibitory effects, with certain modifications enhancing the fungicidal efficacy. The results indicate that the 1,3,4-oxadiazole scaffold including hydroxyaryl and N-aryloxyacetyl groups has the potential to be used to make powerful agrochemical fungicides.