Research Progress on Chronic Pancreatitis

慢性胰腺炎是多种因素导致胰腺组织结构和功能出现不可逆的持续性损害的病理状态，其主要特点是胰腺组织的炎症反应及纤维化，可引起慢性疼痛、胰腺内外分泌功能障碍、生活质量下降以及预期寿命缩短。近年来，该病的发病率呈上升趋势。目前慢性胰腺炎诊断的金标准仍存在争议，诊断时应优先选择影像学检查(CT或MRI)，只有在CT或MRI无法明确诊断或需要进行内镜介入治疗时，才建议使用内镜超声技术。慢性胰腺炎的管理强调多学科协作，包括评估病因、症状控制、处理并发症等。如果患者的症状难以控制或存在恶变的可能，应及时采取进一步治疗措施。Chronic pancreatitis is a pathological condition caused by various factors, leading to irreversible and persistent structural and functional damage to the pancreatic tissue. Its main characteristics include pancreatic inflammation and fibrosis, which can result in chronic pain, endocrine and exocrine pancreatic dysfunction, reduced quality of life, and shortened life expectancy. In recent years, the incidence of this disease has been on the rise. Currently, there is still controversy regarding the gold standard for diagnosing chronic pancreatitis. Imaging examinations (CT or MRI) should be the preferred diagnostic method, and endoscopic ultrasound is only recommended when CT or MRI cannot provide a definitive diagnosis or when endoscopic intervention is required. The management of chronic pancreatitis emphasizes a multidisciplinary approach, including the assessment of etiology, symptom control, and management of complications. If patients' symptoms are difficult to control or there is a risk of malignant transformation, further therapeutic measures should be promptly implemented.