An activatable molecular probe for early detection of obesity-associated aminopeptidase N activity <i>in vivo</i> and in serum
This study develops an activatable optical probe (APNP) for specific detection of aminopeptidase N (APN), a key enzyme in obesity progression. APNP demonstrates high sensitivity, selectivity, and pH stability, enabling real-time monitoring of APN activity <i>in vivo</i>. Using diet-induced obese mice, we show APNP can detect metabolic dysfunction before histological changes occur, highlighting its diagnostic potential.
Authors
- Jie Qiao (ORCID: https://orcid.org/0000-0003-2126-1376)
- Kai Wang (ORCID: https://orcid.org/0000-0002-8326-7178)
- Haoxiang Jiang (ORCID: https://orcid.org/0000-0003-1191-1398)
- Ke Zhu (ORCID: https://orcid.org/0000-0003-1794-1328)
- Zhigang Hu (ORCID: https://orcid.org/0000-0002-8280-8980)
Institutions
- Wuxi Fourth People's Hospital (CN)
- Jiangxi Provincial Children's Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02029h
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00