Cellular Heterogeneity and IL-17 Pathway Dynamics Reveal Insights into the Transition from Ulcerative Colitis to Colorectal Cancer Through scRNA-Seq Analysis
This study uncovers dynamic cellular and molecular changes during the transition from UC to CACRC, highlighting IL-17 signaling, Treg expansion, and C-MYC activation as potential drivers of malignancy and targets for future therapeutic intervention.
Authors
- Bo Yang
- Ruochuan Sun
- Yong‐Jie Lu (ORCID: https://orcid.org/0000-0001-6174-6621)
- Mengdi Ma
- Yong Xiang Li (ORCID: https://orcid.org/0000-0002-7925-8949)
- Huizhen Wang
- Xiaodong Wang (ORCID: https://orcid.org/0000-0001-7114-8780)
- Yaxian Li (ORCID: https://orcid.org/0009-0001-1221-7990)
Institutions
- Anhui Medical University (CN)
- Robert Bosch Hospital (DE)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Robert Bosch (Germany) (DE)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s505313
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82