Mechanistic insights into the regio- and stereoselectivity of [3+2] cycloaddition reactions between <i>N</i>-methyl-phenylnitrone and <i>trans</i>-1-chloro-2-nitroethylene within the framework of molecular electron density theory
The [3+2] cycloaddition of N -methyl-phenylnitrone and trans -1-chloro-2-nitroethylene reveals high ortho regioselectivity and endo stereoselectivity, supported by MEDT and molecular docking studies, suggesting potential for colorectal cancer therapy.
Authors
- Haydar Mohammad‐Salim (ORCID: https://orcid.org/0000-0002-9600-3446)
- Muheb Algso
- Jesus Vicente de Julián‐Ortiz (ORCID: https://orcid.org/0000-0001-9403-8744)
- Mohamed Chellegui (ORCID: https://orcid.org/0009-0004-7818-8573)
- Raad Nasrullah Salih
- Sofiane Benmetir (ORCID: https://orcid.org/0000-0002-2492-2750)
- Raghad Mowafak Al-Mokhtar
- BENHAMED LAKHDAR
Institutions
- University of Sfax (TN)
- University of Namur (BE)
- Universitat de València (ES)
- University of Abou Bekr Belkaïd (DZ)
- Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf (DZ)
- University of Zakho (IQ)
- University of Duhok (IQ)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nj01419k
- Citations
- 8
- Primary Topic
- Organic Chemistry Cycloaddition Reactions
- Type
- article
- Field-Weighted Citation Impact
- 7.49