Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes
The 3D chromatin architecture in B cells is similar across pediatric, adult, and EBV-transformed cell lines. This conservation of 3D structure includes regions encompassing autoimmune risk haplotypes. Thus, even for pediatric autoimmune diseases, publicly available adult B cell and cell line datasets may be sufficient for assessing effects exerted in the 3D genomic space.
Authors
- Lucy Holmes (ORCID: https://orcid.org/0000-0002-5691-9927)
- Kaiyu Jiang (ORCID: https://orcid.org/0000-0003-1212-752X)
- Jennifer A. Kelly (ORCID: https://orcid.org/0000-0002-3203-2467)
- Patrick M. Gaffney (ORCID: https://orcid.org/0000-0002-1580-869X)
- Yao Fu (ORCID: https://orcid.org/0000-0001-9864-1030)
- James N. Jarvis (ORCID: https://orcid.org/0000-0002-1878-0717)
Institutions
- University of Washington (US)
- Oklahoma Medical Research Foundation (US)
- University of Washington Applied Physics Laboratory (US)
- Jacobs Institute (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1186/s12920-025-02166-9
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Institutes of Health
- University at Buffalo
- National Center for Advancing Translational Sciences