Sesquiterpenes with anti-inflammatory activity from the stems and branches of <i>Melicope patulinervia</i>
Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (<b>1</b>-<b>3</b>) and two guaianes, melicopatulones D-E (<b>5</b>-<b>6</b>), were isolated from the stems and branches of <i>Melicope patulinervia</i>, together with melicodenones B (<b>4</b>), C (<b>7</b>) and D (<b>8</b>). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes <b>1</b>, <b>2</b> and <b>6</b> exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.
Authors
- Enzai Du (ORCID: https://orcid.org/0000-0002-5519-0150)
- Shi‐Jin Qu
- Chang‐Heng Tan (ORCID: https://orcid.org/0000-0001-7718-1653)
- Jun‐Jie Tan (ORCID: https://orcid.org/0000-0002-7505-0171)
- Qi Gong (ORCID: https://orcid.org/0000-0001-9565-5701)
- Sai Li (ORCID: https://orcid.org/0000-0003-0253-843X)
- Fei Chen (ORCID: https://orcid.org/0009-0005-4318-6081)
- Hai-Yan Zhang (ORCID: https://orcid.org/0000-0002-5250-1865)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1080/10286020.2025.2508874
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00