FOLR1-Targeted Oxygen-Delivering Nanosomes Enhance Chemo-Induced Apoptosis in Hypoxic Cancer
We demonstrated that multifunctional nanosomes delivering both oxygen and doxorubicin effectively alleviated tumor hypoxia and reduced chemotherapy resistance, thereby enhancing anticancer efficacy. This approach presents a promising strategy for addressing tumor hypoxia and may be broadly applicable as an adjunct to conventional cancer therapies.
Authors
- J. Yang (ORCID: https://orcid.org/0000-0001-6337-3531)
- Jonghoon Choi (ORCID: https://orcid.org/0000-0003-3554-7033)
- Masayoshi Tanaka (ORCID: https://orcid.org/0000-0002-4701-5352)
- Tagbo H. R. Niepa (ORCID: https://orcid.org/0000-0002-3018-5419)
- Gahyun Lee (ORCID: https://orcid.org/0009-0008-1464-1809)
- Jiwon Kim (ORCID: https://orcid.org/0000-0002-7412-161X)
- Heeyoung Lee (ORCID: https://orcid.org/0000-0003-3179-0386)
- Jaehee Jang
- Yoon Jung Jang (ORCID: https://orcid.org/0009-0004-4716-2610)
Institutions
- Kumoh National Institute of Technology (KR)
- Tokyo Institute of Technology (JP)
- Teradyne (United States) (US)
- CIBBIM-Nanomedicine (ES)
- Chung-Ang University (KR)
- Carnegie Mellon University (US)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ijn.s513688
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Research Foundation
- Ministry of Trade, Industry and Energy
- Ministry of Environment
- National Research Foundation of Korea
- Ministry of Education, India
- Ministry of Science and ICT, South Korea
- Korea Environmental Industry and Technology Institute