<i>Listeria monocytogenes</i> Endophthalmitis—Good Outcome With Rapid Diagnosis Using MALDI‐TOF and Treatment With Benzylpenicillin and Trimethoprim–Sulfamethoxazole

<b>Purpose:</b> Describe a case of rapidly diagnosed <i>Listeria monocytogenes</i> endophthalmitis, with a clearly established route of endogenous seeding, treated with dual antibiotics, with outcomes better than many reported. <b>Observations:</b> A 79-year-old male developed <i>Listeria monocytogenes</i> endophthalmitis after a gastrointestinal infection with an associated bacteraemia. Rapid microbiologic diagnosis was obtained via matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF). The case was managed with 3 weeks of benzylpenicillin and 6 weeks of trimethoprim-sulfamethoxazole. Visual acuity in the affected eye was preserved with a mild to moderate residual deficit. <b>Conclusion:</b> Clinicians should be aware of the potential for <i>Listeria monocytogenes</i> endophthalmitis associated with preceding gastrointestinal symptoms. Better outcomes are associated with rapid diagnosis, and the use of dual antimicrobial therapy should be considered.