Photoredox‐Catalyzed α‐Arylation of Bromotrifluoroacetone with Electron‐Rich (Hetero)Arenes
Abstract Photoredox‐catalyzed radical addition of bromotrifluoroacetone and (hetero)arenes to carbonyl compounds has been established under mild conditions. The proposed method enables the synthesis of valuable α‐aryl trifluoromethyl ketone compounds, including biologically relevant arene derivatives, with good yields and regioselectivities. This method eliminates competitive bromination using Zn(OAc) 2 as an additive.
Authors
- Satoshi Mizuta (ORCID: https://orcid.org/0000-0002-9023-7671)
- Tomoko Yamaguchi (ORCID: https://orcid.org/0000-0001-9482-8738)
- Takeshi Ishikawa (ORCID: https://orcid.org/0000-0002-3187-1381)
- Masaharu Iwasaki
Institutions
- Kagoshima University (JP)
- Nagasaki University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1002/slct.202502626
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science