Gastro protective potential of Citrus limetta Risso fruit juice in Ethanol induced gastric ulcer Mice model

Introduction: Peptic ulcer is a disease of GIT that results ofchronically inequityof endogenous gastro protective factors and destructive factors. The primary cause of the erosion of mucosal layer may befactors like smoking, poor diet, excessive intake of alcohol, NSAIDs and H. pylori infection. Phytochemical screening of Citrus Limetta Risso confirms the presence of alkaloids, glycosides, saponins, flavonoids, anthraquinones, phenolics, tannins, and terpenes. According to literature cited by various authors alkaloids, flavonoids, and D-limonene present in Citrus Limetta Risso have the potential for antiulcer activity. Methods: Present study aimed at investigating the gastro protective effects of Citrus limetta against ethanol-induced gastric ulcers in mice using famotidine as a control drug. Ethanol induced gastric ulcer model in mice was used for evaluation; ulcer index was calculated by scoring the ulcers. Biochemical estimation of stomach tissues were completed by SOD, GSH, LPO, catalase methods. Results: The results of findings demonstrated that the mice group pre-treated with C. limetta juice significantly lower the GUI and raised the ulcer inhibition rate of gastric ulcers. Conclusion: Mechanism behind the C. limetta juice may be neutralization reactionwith gastric acid, further studies required so that it could be used as alternate to currently used antiulcer drugs.