PET imaging of TREM2 in amyloid-beta induced neuroinflammation
These findings highlight IgG-scFv<sub>2</sub> as a promising radioligand for in vivo PET imaging of TREM2, advancing non-invasive neuroinflammation studies and supporting drug development for AD and other neurodegenerative diseases.
Authors
- Stina Syvänen (ORCID: https://orcid.org/0000-0002-8196-4041)
- Dag Sehlin (ORCID: https://orcid.org/0000-0002-9430-3859)
- Amelia D. Dahlén (ORCID: https://orcid.org/0000-0002-5765-1002)
- Sara Lopes van den Broek (ORCID: https://orcid.org/0000-0002-3874-6962)
- Sahar Roshanbin (ORCID: https://orcid.org/0000-0003-0339-831X)
- Ximena Aguilar (ORCID: https://orcid.org/0000-0001-7601-8862)
- Nadja M Bucher
Institutions
- Uppsala University (SE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1007/s00259-025-07358-0
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.11
Funders
- Vetenskapsrådet
- Uppsala Universitet
- Parkinsonfonden
- RIKEN