Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain
These findings suggest that HIV infection accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain, which may explain the complex mechanisms underlying cognitive impairment in motor and executive domains often seen in HIV patients. These new insights may shift our understanding of HIV pathology and aid the development of new therapeutic targets, contrary to previous approaches.
Authors
- Han Jin (ORCID: https://orcid.org/0000-0003-0148-9031)
- Peter Shaw (ORCID: https://orcid.org/0000-0002-3187-8938)
- Yifei Han (ORCID: https://orcid.org/0000-0002-8410-0660)
- Benedictor Alexander Nguchu (ORCID: https://orcid.org/0000-0003-4146-1877)
- Jing Zhao (ORCID: https://orcid.org/0000-0001-7346-9959)
- Hongjun Li (ORCID: https://orcid.org/0000-0001-5553-6062)
- Xiaoxiao Wang (ORCID: https://orcid.org/0000-0001-5173-6497)
- Lu Yu (ORCID: https://orcid.org/0009-0007-9449-8274)
Institutions
- University of Science and Technology of China (CN)
- Tianjin University of Technology and Education (CN)
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Zhejiang Lab (CN)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-05-28
- DOI
- https://doi.org/10.3389/fpsyt.2025.1509093
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China