B-Raf kinase blockade protects airway epithelial cells against respiratory syncytial virus infection and modulates interferon responses
Collectively, our data indicate that B-Raf kinase is involved in RSV replication, interferon-stimulated gene induction, and type I and III interferon release in airway epithelial cells following infection. We propose that repurposing dabrafenib as a host-directed antiviral against RSV may be valuable in reducing disease pathogenesis associated with RSV infection.
Authors
- Julia A. Cerato (ORCID: https://orcid.org/0000-0002-7049-9498)
- Theo J. Moraes (ORCID: https://orcid.org/0000-0001-9968-6601)
- René P. Zahedi (ORCID: https://orcid.org/0000-0002-4960-5460)
- Wenming Duan
- Deanna M. Santer (ORCID: https://orcid.org/0000-0001-6169-7735)
- Rasha Salih
- Sowmya Thanikachalam
- Testimony Olumade (ORCID: https://orcid.org/0000-0002-5046-153X)
- Bárbara N. Porto (ORCID: https://orcid.org/0000-0002-1995-9874)
- Kevin M. Coombs (ORCID: https://orcid.org/0000-0001-7667-8430)
- Maria Serda
- M. Immanuel Reyes Madlangsaka
Institutions
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Research Manitoba (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1183/23120541.00307-2025
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital Research Institute of Manitoba
- Max Rady College of Medicine, University of Manitoba
- Canadian Institutes of Health Research