TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cells
TRPM2 channels and TRPM2-mediated Zn<sup>2+</sup> are essential in ROS-induced actin remodeling and cell migration in prostate cancer cells. Preventing TRPM2 channel activation and chelating Zn<sup>2+</sup> may offer potential therapeutic strategies for preventing cancer metastasis. Further research is needed to identify molecular targets of Zn<sup>2+</sup> in the actin cytoskeleton and cancer cell migration.
Authors
- Xiangming Ye (ORCID: https://orcid.org/0000-0003-2230-6329)
- Hongtian Zhang
- Xingyu Liu (ORCID: https://orcid.org/0000-0002-9649-189X)
- Qing You (ORCID: https://orcid.org/0000-0002-2199-1152)
- Pengwei Qi
- Jing Zhao (ORCID: https://orcid.org/0009-0009-0139-5538)
- Fangfang Li
- Jianguo Niu (ORCID: https://orcid.org/0000-0003-2250-3592)
Institutions
- Ningxia Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1186/s12885-025-14333-3
- Citations
- 3
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 4.39
Funders
- National Natural Science Foundation of China
- Zhejiang University