Impact of a Sepsis Quality Improvement Initiative on Clinical and Operational Outcomes

<b>Background/Objectives:</b> Sepsis is a costly and life-threatening condition caused by a dysregulated host response to infection. Lack of a reliable, timely diagnostic for sepsis leads to under- and overdiagnosis, suboptimal outcomes, and strained hospital resources. Our Lady of the Lake Regional Medical Center (OLOLRMC) implemented a sepsis learning health program to evaluate and improve outcomes through standardized ED workflows and the incorporation of a novel sepsis diagnostic test. <b>Methods:</b> We report the results of the first year of experience following the implementation of the learning health initiative and sepsis testing. Data from the Epic EHR were analyzed across two groups: pre-implementation (April 2023-July 2023) vs. post-implementation (August 2023-July 2024), and temporally matched cohorts (April-July 2023 vs. April-July 2024). We assessed clinical outcomes (sepsis-associated mortality, hospital length of stay, or HLOS), and resource utilization (antibiotic use, blood cultures). <b>Results:</b> Post-implementation, sepsis-associated mortality dropped from 10.9% to 6.6% in the temporally matched group (<i>p</i> < 0.001). There was also a 0.76-day reduction in mean HLOS among sepsis DRG patients (<i>p</i> < 0.05). Blood culture utilization fell from 50.8% to 45.7%, driven by reductions in blood culture utilization among patients receiving a Band 1 IntelliSep score. <b>Conclusions:</b> The FMOLHS experience demonstrated significant benefits to patient outcomes and resource utilization after implementing a sepsis QI initiative including protocolized and standardized ED workflows via a nurse-driven triage system with sepsis testing for the early risk stratification of patients who present to the ED with signs and symptoms of infection.