Assessment of thiopurine S-methyltransferase allele frequencies and phenotype–genotype concordance in a Tunisian population
Overall, 12.5 % of the Tunisian subjects were found to carry the <i>TPMT</i> *3C allele. However, detecting novel and rare TPMT alleles within a larger cohort essential for more accurate estimation of genotype-phenotype correlation in our population. Combining genotyping and phenotyping is likely represents the most effective approach to prevent life-threatening myelosuppression associated with thiopurines.
Authors
- Syrine Ben Hammamia (ORCID: https://orcid.org/0000-0001-6625-6648)
- Emna Gaïes
- Hanène El Jebari
- Wissem Ben Azzouz
- Mouna Daldoul (ORCID: https://orcid.org/0000-0001-6395-9049)
- Rim Charfi (ORCID: https://orcid.org/0000-0002-7714-3670)
- Riadh Daghfous
- Mohamed Zouari (ORCID: https://orcid.org/0000-0001-9491-816X)
- Sameh Trabelsi (ORCID: https://orcid.org/0009-0003-6351-4703)
- Mouna Ben Sassi (ORCID: https://orcid.org/0000-0002-7672-4684)
- Safa Souissi (ORCID: https://orcid.org/0009-0007-5362-3921)
Institutions
- Faculté de médecine de Tunis
- Tunis El Manar University (TN)
Publication Details
- Journal
- Drug Metabolism and Personalized Therapy
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1515/dmpt-2025-0001
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00