A novel approach to evaluate the therapeutic efficacy of durvalumab and tremelimumab combination therapy in hepatocellular carcinoma
In real-world clinical practice, Dur + Tre is highly effective as a first-line treatment for u-HCC. Additionally, patients with SD who met the SD-R criteria (PFS ≥84 days or RECIST DOR ≤-10%) showed survival outcomes comparable to those of patients with PR or CR. These findings may help identify patients who are most likely to benefit from treatment and improve their prognoses.
Authors
- Hideki Kobara (ORCID: https://orcid.org/0000-0002-8508-827X)
- Yasuto Takeuchi (ORCID: https://orcid.org/0000-0003-3261-0842)
- Norikazu Tanabe (ORCID: https://orcid.org/0009-0005-9502-8886)
- Joji Tani (ORCID: https://orcid.org/0000-0001-8801-2505)
- Hironori Tanaka (ORCID: https://orcid.org/0000-0003-4712-0192)
- Yuki Kanayama (ORCID: https://orcid.org/0000-0002-8639-5212)
- Yasushi Sato (ORCID: https://orcid.org/0000-0002-6776-4609)
- Hisamitsu Miyaaki (ORCID: https://orcid.org/0000-0002-8067-4376)
- Takeshi Hatanaka (ORCID: https://orcid.org/0000-0003-3656-285X)
- Tetsuji Takayama (ORCID: https://orcid.org/0000-0002-0175-1573)
- Tetsu Tomonari
- Yuichi Honma (ORCID: https://orcid.org/0000-0001-7112-3479)
- Shigeo Shimose (ORCID: https://orcid.org/0000-0003-2068-8386)
- Yutaka Kawano (ORCID: https://orcid.org/0000-0002-2256-0776)
- Ryu Sasaki (ORCID: https://orcid.org/0000-0002-0001-7377)
- Kyo Sasaki
- Motoyuki Otsuka (ORCID: https://orcid.org/0000-0003-2869-2881)
- Sohji Nishina (ORCID: https://orcid.org/0009-0002-5803-4986)
- Atsushi Naganuma (ORCID: https://orcid.org/0000-0003-0663-0102)
- Hiroki Kawashima (ORCID: https://orcid.org/0000-0002-3720-781X)
- Issei Saeki (ORCID: https://orcid.org/0000-0001-5885-5042)
- Takanori Ito (ORCID: https://orcid.org/0000-0002-2594-0854)
- Masaru Harada (ORCID: https://orcid.org/0000-0001-9891-3526)
- Taro Takami (ORCID: https://orcid.org/0000-0002-6689-4989)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0003-0224-7093)
- Takumi Kawaguchi (ORCID: https://orcid.org/0000-0002-7064-4325)
- Takehito Naito
- Mamiko Takeuchi
Institutions
- Kurume University (JP)
- Yamaguchi University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Kawasaki Medical School (JP)
- Kagawa University (JP)
- Nagoya University Hospital (JP)
- Okayama University Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Anjo Kosei Hospital (JP)
- Toyohashi Municipal Hospital (JP)
- Tokushima Breast Care Clinic (JP)
- Nagasaki University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1111/hepr.14212
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00