Methylation Status of the Telomerase Reverse Transcriptase Promoter in Parotid Tumours and Adjacent Parotid Gland Tissue: A Pilot Study on the Implications for Recurrence and Development of Malignancy
THOR methylation may add information to differentiate normal from carcinogenic tissues and, as such, may be included in a biomarkers panel. Epigenetic alterations in PA-adjacent tissues with normal histology highlight the need for improved diagnostic markers.
Authors
- Nádia Silva (ORCID: https://orcid.org/0000-0001-9881-4421)
- Pedro Castelo‐Branco (ORCID: https://orcid.org/0000-0002-3453-3978)
- Joana Apolónio (ORCID: https://orcid.org/0000-0002-9727-1813)
- José Ricardo Brandão (ORCID: https://orcid.org/0000-0002-5861-5409)
- Alfons Nadal (ORCID: https://orcid.org/0000-0002-5366-093X)
- António Paiva‐Correia (ORCID: https://orcid.org/0000-0001-8725-0202)
- Iván Archilla (ORCID: https://orcid.org/0000-0002-2142-0608)
- Bianca Machado (ORCID: https://orcid.org/0000-0002-4953-3022)
- Henrik Hellquist
Institutions
- Champalimaud Foundation (PT)
- Universidade do Porto (PT)
- Manchester University NHS Foundation Trust (GB)
- Northern Lincolnshire and Goole Hospitals NHS Foundation Trust (GB)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- IPO Porto (PT)
- Hospital Clínic de Barcelona (ES)
- Algarve Biomedical Center (PT)
- Wythenshawe Hospital (GB)
- University of Algarve (PT)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Current Oncology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.3390/curroncol32060312
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia