Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue
Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lymphocytes to subvert their function in cancer immunosurveillance.
Authors
- Oliver Kepp (ORCID: https://orcid.org/0000-0002-6081-9558)
- Guido Kroemer (ORCID: https://orcid.org/0000-0002-9334-4405)
- Liwei Zhao (ORCID: https://orcid.org/0000-0001-5077-327X)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
Institutions
- Inserm (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Européen (FR)
Publication Details
- Journal
- OncoImmunology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1080/2162402x.2025.2512109
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Association pour la Recherche sur le Cancer
- Seerave Foundation
- Fondation pour la Recherche Médicale
- Institut Universitaire de France
- Institut National Du Cancer
- Cancéropôle Ile de France
- Ministère des Solidarités et de la Santé
- HORIZON EUROPE European Innovation Council