Hydrogen Bond-Controlled Site-Selective C–H Borylation at the Remote-Position of Naphthalene Derivatives

Abstract We successfully developed site-selective C–H borylation at the remote position (6-position) of 1-substituted naphthalene derivatives, which was controlled by hydrogen bonding between the substrate-recognition site of the catalyst (hydrogen bond donor) and the functional group of the substrate (hydrogen bond acceptor). By changing the ligands, 7-position-selective remote C–H borylation of naphthalene derivatives with a functional group at the 2-position can also be achieved. These are rare examples of site-selective C–H borylation at a remote position of naphthalene derivatives.