Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging
A simplified D-π-A hemicyanine probe CCX-1 was rationally designed and synthesised <i>via</i> a one-step condensation reaction. CCX-1 exhibits dual-responsive fluorescence behavior towards pH and viscosity changes, along with specific lysosomal targeting capability. Notably, CCX-1 enables discrimination between tumor and normal cells, and tumor visualization in living mice, showing significant potential for precise cancer imaging and diagnosis.
Authors
- Daoyuan Chen (ORCID: https://orcid.org/0000-0002-3090-6669)
- Jia‐Qiang Wu (ORCID: https://orcid.org/0000-0001-5067-7616)
- Qingxiu Chen (ORCID: https://orcid.org/0009-0001-6388-8495)
- Ruping Li
- Chunli Xia
- Shun Li (ORCID: https://orcid.org/0000-0003-1102-5572)
- Shuanglong Li
- Peipei Tong
Institutions
- Zunyi Medical University (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Analytical Methods
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ay00577a
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Guizhou Science and Technology Department
- Department of Education of Guangdong Province