Real-World Effectiveness of Boosting Against Omicron Hospitalization in Older Adults, Stratified by Frailty
First boosters were associated with reduced adverse COVID-19 outcomes across all frailty categories in infection-naïve older adults during Omicron. However, in the high-frailty minority, boosting did not additionally reduce risk in reinfected individuals with hybrid immunity, and beyond the first booster for infection-naïve individuals.
Authors
- Barbara Helen Rosario (ORCID: https://orcid.org/0000-0001-5491-3524)
- Christopher Lien (ORCID: https://orcid.org/0000-0003-0214-0501)
- Calvin J. Chiew (ORCID: https://orcid.org/0000-0002-8217-7971)
- David Chien Lye (ORCID: https://orcid.org/0000-0003-0324-0205)
- Liang En Wee (ORCID: https://orcid.org/0000-0001-6428-9999)
- Reshma Aziz Merchant (ORCID: https://orcid.org/0000-0002-9032-0184)
- Jue Tao Lim (ORCID: https://orcid.org/0000-0002-2245-0331)
- Kelvin Bryan Tan
- Ian Yi Onn Leong
- En Yun Loy
- Wei Hao Kwok
Institutions
- Ministry of Health (SG)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Singapore General Hospital (SG)
- Changi General Hospital (SG)
- Tan Tock Seng Hospital (SG)
- Duke-NUS Medical School (SG)
- National University Hospital (SG)
- National Centre for Infectious Diseases (SG)
Publication Details
- Journal
- Vaccines
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3390/vaccines13060565
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00