Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense

<b>Background:</b> Thiamine deficiency requires supplementation to prevent or reverse severe clinical complications. Are supplementation protocols correctly tailored in neurology? <b>Methods:</b> An examination of recommended thiamine supplementation protocols is undertaken. <b>Results:</b> Recommended thiamine levels are much higher than required, reaching a median daily intake and total amount of 7.8-fold and 30.6-fold greater than the whole-body thiamine store, respectively. The high initial intake is often followed by tapering over days or weeks. <b>Conclusions:</b> Thiamine supplementation protocols in neurology mostly recommend far higher doses than those biologically required and could probably be simplified to a single 100 mg dose injected as early as possible.