Molecular blueprint of a cellular sorting centre

Endosomes are sorting centres inside cells that decide where to deliver materials that are taken from outside or from other parts of the cell. A comprehensive map of endosomal proteins uncovers new components, and reveals the assembly and architecture of hundreds of molecular machines that work together in the endosomal system. Experimental techniques and the AI tool AlphaFold are used to generate a comprehensive map of early endosomal proteins and their interactions.

Publication Details

Journal
Nature
Published
2025-05-28
DOI
https://doi.org/10.1038/d41586-025-01564-4
Primary Topic
Cellular transport and secretion
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular blueprint of a cellular sorting centre

Nature
Cellular transport and secretion
article

Molecular blueprint of a cellular sorting centre

article en

Abstract

Endosomes are sorting centres inside cells that decide where to deliver materials that are taken from outside or from other parts of the cell. A comprehensive map of endosomal proteins uncovers new components, and reveals the assembly and architecture of hundreds of molecular machines that work together in the endosomal system. Experimental techniques and the AI tool AlphaFold are used to generate a comprehensive map of early endosomal proteins and their interactions.

Nature
Openalex Percentile: Top 88%
Cellular transport and secretion
DOIOpen Access PDFOpenAlex
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Molecular blueprint of a cellular sorting centre · Nature (2025) | TGRS Research Map | TGRS