Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells
Lung cancers develop from genetic and epigenetic changes that can dramatically influence patients' susceptibility to viral infection and replication. This study evaluates the responses to influenza virus infection of two patient-derived lung cancer cell lines. Interestingly, the cell lines investigated are of the same cancer type, lung adenocarcinomas, yet one cell line is highly susceptible, while the other cell line is highly resistant to viral infection. This is in part due to contrasting genetic alterations that lead to changes in the interferon response pathways, which differentially impact viral entry. Thus, identifying these risk factors can inform the prognosis of patients infected with influenza virus and guide their personalized treatment plans.
Authors
- Adolfo Garcı́a-Sastre (ORCID: https://orcid.org/0000-0002-6551-1827)
- Beatriz M. A. Fontoura (ORCID: https://orcid.org/0000-0001-8468-5315)
- Luc Girard (ORCID: https://orcid.org/0000-0002-6688-5281)
- Hanspeter Niederstrasser
- Umut Karakus (ORCID: https://orcid.org/0000-0002-6392-7765)
- John D. Minna (ORCID: https://orcid.org/0000-0002-7776-0767)
- Boning Gao (ORCID: https://orcid.org/0000-0002-1382-395X)
- Bruce A. Posner (ORCID: https://orcid.org/0000-0002-7033-4933)
- Sara S. El Zahed (ORCID: https://orcid.org/0000-0002-0039-1780)
- Kimberly Batten
- Fred R. Hirsch (ORCID: https://orcid.org/0000-0002-6885-1894)
- Matthew A. Esparza (ORCID: https://orcid.org/0000-0001-5277-0398)
- Jerry W. Shay
- Lily Huang
Institutions
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1128/jvi.00469-25
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health