EFFECT OF 2% PROPOFOL INFUSION VS 1% PROPOFOL INFUSION ON LIPID PROFILE AND HAEMODYNAMICS OF POST CARDIAC SURGERY PATIENTS ON MECHANICAL VENTILATION: A PROSPECTIVE COMPARATIVE OBSERVATIONAL STUDY

Introduction: Propofol is widely used for sedation in post-cardiac surgery patients, but concerns exist regarding its effects on lipid metabolism and hemodynamics. This study aimed to compare the effects of 2% propofol infusion versus 1% propofol infusion on lipid proles and hemodynamic parameters in post- cardiac surgery patients on mechanical ventilation. Methods: In this prospective comparative observational study, 86 post-cardiac surgery patients were equally divided into two groups: Group A receiving 2% propofol (n=43) and Group B receiving 1% propofol (n=43). Lipid proles, including total cholesterol, triglycerides, HDL, and LDL, were assessed pre- operatively and at 24 and 48 hours post-infusion. Hemodynamic parameters, including heart rate, blood pressure, and SpO2, were monitored at regular intervals. Results: A trend towards higher total cholesterol levels was observed in the 2% propofol group at 48 hours, but this was not statistically signicant (p=0.053). No signicant differences were found in triglycerides, HDL, or LDL levels between the groups. The 2% propofol group showed signicantly higher heart rates at the end of infusion (p=0.005). The 1% propofol group demonstrated higher diastolic blood pressure and mean arterial pressure at 12 and 18 hours post-infusion (p<0.001 and p=0.003, respectively). SpO2 levels were signicantly higher in the 1% propofol group at 6, 12, and 18 hours post-infusion (p<0.001). Conclusion: Both 1% and 2% propofol infusions appear to be safe options for sedation in post-cardiac surgery patients on mechanical ventilation, with some differences in hemodynamic effects. The choice between concentrations may depend on specic patient requirements. Further research is needed to determine the long-term clinical implications of these ndings.