Decatungstate-catalyzed α-C(sp<sup>3</sup>)–H functionalization of amides with <i>para</i>-quinone methides
An efficient photocatalytic strategy for the synthesis of <i>N</i>-methylformamide-modified diarylmethane scaffolds that involves the 1,6-conjugate addition of a <i>para</i>-quinone methide to amides <i>via</i> a tetrabutylammonium-decatungstate-catalyzed hydrogen atom transfer process has been described. This protocol features mild conditions, operational ease, and good-to-excellent yields (up to 92%), and is broadly compatible with a variety of functional groups.
Authors
- Hongyu Chen (ORCID: https://orcid.org/0000-0002-7950-9824)
- Lin He
- Mingsong Shi (ORCID: https://orcid.org/0000-0002-8979-5844)
- Xile Jiang
- Liyuan Cheng
- Dan Yang (ORCID: https://orcid.org/0000-0001-9984-7225)
Institutions
- University of Electronic Science and Technology of China (CN)
- China West Normal University (CN)
- Sichuan University (CN)
- Mianyang Central Hospital (CN)
- Wuxi Taihu Hospital (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00619h
- Citations
- 1
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province