Challenges in Human-Compatible AI for Well-being: Harnessing Potential of GenAI for AI-Powered Science

At the AAAI Spring Symposium 2025, we explored the challenges of integrating Human-Compatible AI and AI-Powered Science to enhance social and individual well-being. Our discussion was guided by two perspectives. Individual Impact of AI on Well-being: This perspective examines how AI influences personal autonomy, mental health, and emotional fulfillment. It seeks to ensure that AI enhances individual agency, rather than undermining critical thinking and independence. Social Impact of AI on Well-being: This perspective focuses on the broader societal implications of AI, including fairness, misinformation, and economic impact. It emphasizes AI's role in fostering inclusive social structures while mitigating risks, such as bias and automation-driven unemployment. This paper provides an overview of the motivations driving our exploration, defines key concepts, outlines major research challenges, and proposes strategies for integrating Human-Compatible AI and AI-Powered Science in a manner that balances innovation with ethical responsibility.