Mitigating the Oncogenic Roles of miR-629-5p and miR-660-5p Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention

The study's findings suggest that miR-629-5p and miR-660-5p may have potential as predictive biomarkers and treatment targets for Preventing CRC and that Regorafenib and DIM may have miRNA binding properties. They indicated a high affinity to miRNA-629-5p compared with miRNA-660-5p created a slight change in its structure and can suppress its activity in CRC. However, extra experimental approaches are needed to approve our hypothesis.

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Publication Details

Journal
International Journal of Preventive Medicine
Published
2025-05-01
DOI
https://doi.org/10.4103/ijpvm.ijpvm_277_24
Citations
1
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.94
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article

Mitigating the Oncogenic Roles of miR-629-5p and miR-660-5p Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention

Elham Amjadi, Mohammad Ali Abdolvand, Fatemeh Maghool, Mohammad Hassan Emami et al.
1 citations
International Journal of Preventive Medicine
MicroRNA in disease regulation
0.94
article

Mitigating the Oncogenic Roles of miR-629-5p and miR-660-5p Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention

Elham Amjadi, Mohammad Ali Abdolvand, Fatemeh Maghool, Mohammad Hassan Emami, Fariborz Poorbaferani, Alireza Fahim, Simin Hemati, Shirin Abdolvand, Fatemeh Aghaie-Kheyrabadi, Nooshin Farhadian, Hojjatolah Rahimi, F. Del Bon, Mansoor Salehi, Soheil Bolandi
article en
1 citations

Abstract

The study's findings suggest that miR-629-5p and miR-660-5p may have potential as predictive biomarkers and treatment targets for Preventing CRC and that Regorafenib and DIM may have miRNA binding properties. They indicated a high affinity to miRNA-629-5p compared with miRNA-660-5p created a slight change in its structure and can suppress its activity in CRC. However, extra experimental approaches are needed to approve our hypothesis.

International Journal of Preventive MedicineVol. 16
Isfahan University of Medical Sciences (IR), Shahrekord University (IR), Shiraz University of Medical Sciences (IR), University of Isfahan (IR), Islamic Azad University of Shahrekord (IR), Payame Noor University (IR)
Good health and well-being
Openalex Percentile: Top 24%
MicroRNA in disease regulation
0.94
DOIOpen Access PDFOpenAlex
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Mitigating the Oncogenic Roles of miR-629-5p and miR-660-5p Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention — Elham Amjadi, Mohammad Ali Abdolvand, et al. · International Journal of Preventive Medicine (2025) | TGRS Research Map | TGRS