Analyzing trends in multimorbidity-related mortality among patients with cancer and myocardial infarction: A decadal analysis.

10534 Background: Multimorbidity, defined as the coexistence of two or more chronic conditions, poses major challenges to healthcare systems globally. Cancer and myocardial infarction (MI) are leading causes of mortality, yet their combined impact remains underexplored. This study investigates trends in multimorbidity-related mortality among U.S. patients with cancer and MI over two decades, aiming to identify patterns and correlations to guide healthcare interventions and policies. Methods: Data were extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2020. Death certificates were analyzed for adults aged 25 years and older, with cancer and MI deaths identified using ICD-10 codes (I20 and C00–C97). Variables such as age, sex, race/ethnicity, geographical region, urban-rural classification, and location of death were extracted. Crude and age-adjusted mortality rates (AAMR) per 100,000 population were calculated and Join point regression analysis was employed to assess mortality trends and annual percent changes (APC). Statistical significance was defined at p < 0.05. Results: A total of 200,884 deaths were analyzed, with 59.9% occurring in medical facilities, followed by deaths at home (25.09%), nursing homes (12.85%), and hospice facilities (2.10%). The overall AAMR declined significantly from 6.83 in 1999 to 3.33 in 2020.Males consistently had higher mortality, with AAMR dropping from 10.85 to 4.79, compared to females (4.30 to 2.22). The highest mortality was observed in individuals aged 85 and above (CMR: 41.42). Mortality trends declined across all age groups until stabilization in recent years. Racial disparities persisted, with NH Black/African Americans experiencing higher mortality rates (8.91 in 1999 to 3.92 in 2020). Geographic analysis showed the highest mortality rates in the Midwest and Northeast regions. Metropolitan and non-metropolitan areas showed declining mortality trends until 2015, followed by stabilization or slight increases in recent years. Conclusions: A significant decline in multimorbidity-related mortality has been observed in patients with cancer and MI over the past two decades, with notable disparities across gender, age, race, and geography. Targeted healthcare strategies are essential to address the specific needs of high-risk populations and ensure equitable access to healthcare resources.