Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation
The study provides compelling evidence for the antitumor activity of Polyphyllin I in HCC and elucidates its possible molecular mechanisms, suggesting that Polyphyllin I holds great potential as a therapeutic agent for HCC.
Authors
- Jiamei Le (ORCID: https://orcid.org/0000-0002-4776-1347)
- Jie Xiong (ORCID: https://orcid.org/0000-0002-6350-5853)
- Yilong Chen (ORCID: https://orcid.org/0009-0002-3792-3303)
- Qiuying Wang (ORCID: https://orcid.org/0009-0007-9596-1312)
- S. Bian (ORCID: https://orcid.org/0009-0003-6056-8079)
- Jing Dong (ORCID: https://orcid.org/0000-0002-3684-2432)
Institutions
- Nanjing University of Chinese Medicine (CN)
- University of Shanghai for Science and Technology (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1007/s12672-025-02341-5
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Key Laboratory of Molecular Imaging