Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina
Clofarabine safely enhances rAAV2 transduction efficiency in both ocular cell models and murine retinas. Its ability to synchronize cell cycles in dividing cells and reprogram transcriptional landscapes in postmitotic cells positions it as a promising adjunct for rAAV-based ocular gene therapy, potentially decreasing therapeutic vector doses and improving clinical outcomes.
Authors
- Guei‐Sheung Liu (ORCID: https://orcid.org/0000-0003-3379-724X)
- Xingbo Teng
- Yuyao Diao
- Xuewei Xiong (ORCID: https://orcid.org/0009-0005-7310-434X)
- Guocheng Yu
- Jiayan Liu (ORCID: https://orcid.org/0000-0003-2798-8795)
- Leilei Tu
- Yahui Lei
- Shisi Ma (ORCID: https://orcid.org/0000-0002-2795-2250)
- Lian Liu (ORCID: https://orcid.org/0000-0001-5868-4482)
- Jiang-Hui Wang
- Jingxiang Zhong (ORCID: https://orcid.org/0000-0003-3204-5329)
- Qi Shi
- Seung-Won Jin
Institutions
- University of Tasmania (AU)
- Jinan University (CN)
- The University of Melbourne (AU)
- Centre for Eye Research Australia (AU)
- Zhujiang Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1167/iovs.66.5.42
- Citations
- 1
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- American Australian Association
- Retina Australia
- National Natural Science Foundation of China
- Jinan University
- Division of Graduate Education