Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer
Our findings reveal a previously unrecognized non-canonical metabolic function of PHGDH, thus providing potential therapeutic targets in the tumor microenvironment for reversing malignant progression.
Authors
- Zhenkun Na
- Pei Wang (ORCID: https://orcid.org/0000-0002-1682-566X)
- Wenkui Fu
- Jiaxin Zhong
- Hongde Li (ORCID: https://orcid.org/0000-0003-1256-2513)
- Junying Yuan (ORCID: https://orcid.org/0000-0003-2405-6036)
- Z C Han
- Xin Du
- Lin Jiang (ORCID: https://orcid.org/0000-0002-7750-7294)
- Hai Hu (ORCID: https://orcid.org/0000-0001-6338-7431)
- Beinan Han
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-05-28
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2024.0398
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province