Inflammatory biomarkers as predictors for unlocking antidepressant efficacy: Assessing predictive value and risk stratification in major depressive disorder in a prospective longitudinal study
Baseline ANC and eosinophil count may help stratify MDD treatment outcomes, though post-treatment biomarker changes were not linked to symptom improvement. Our findings highlight suicidality as a distinct pathology within depression, necessitating tailored interventions. This study highlights the complexity of inflammation in depression and suicidality, emphasizing the need for advanced biomarkers utilization in precision medicine and personalized psychiatry treatment.
Authors
- Sami Ouanes (ORCID: https://orcid.org/0000-0003-0867-060X)
- Mohamed Adil Shah Khoodoruth (ORCID: https://orcid.org/0000-0003-3104-7525)
- Ahmed Karawia
- Saad M. Mahmoud (ORCID: https://orcid.org/0009-0001-5553-729X)
- Noriya Al‐Khuzaei
- Nervana Elbakary (ORCID: https://orcid.org/0000-0003-1522-4034)
- Tarteel Ali Hussain (ORCID: https://orcid.org/0000-0003-1336-6821)
- James D. Currie (ORCID: https://orcid.org/0000-0002-0061-3849)
- Malek Smida
- Niveen Abu-Rahma
- Fairooz Akel
Institutions
- Western University (CA)
- Hamad Medical Corporation (QA)
- Qatar University (QA)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.jad.2025.119545
- Citations
- 9
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.20
Funders
- Hamad Medical Corporation
- Qatar National Library