Combination astragaloside IV and artesunate preserves blood–brain barrier integrity by modulating astrocytes and tight junction proteins in Plasmodium yoelii infection
ASIV exhibited modest antiparasitic action and robust anti-inflammatory effects, alleviating BBB disruption when combined with ART in Py 17XL-infected mice. These findings provide an essential basis for further preclinical exploration of ASIV as an adjunct therapy in severe malaria.
Authors
- Ingrid Y. Liu (ORCID: https://orcid.org/0000-0002-2795-2461)
- Ladawan Khowawisetsut (ORCID: https://orcid.org/0000-0003-1585-495X)
- Lanaprai Kwathai
- Chairat Turbpaiboon (ORCID: https://orcid.org/0000-0001-9609-3034)
- Supin Chompoopong (ORCID: https://orcid.org/0000-0003-3709-308X)
- Panapat Uawithya
- Prasert Sobhon (ORCID: https://orcid.org/0000-0003-4018-5487)
- Peeraporn Varinthra (ORCID: https://orcid.org/0000-0001-8070-5016)
- Phornyupa Sanguanwong
Institutions
- Siriraj Hospital (TH)
- Tzu Chi University (TW)
- Mahidol University (TH)
Publication Details
- Journal
- International Journal for Parasitology Drugs and Drug Resistance
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.ijpddr.2025.100598
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00