MicroRNA-29a-5p attenuates hemorrhagic transformation and improves outcomes after mechanical reperfusion for acute ischemic stroke
MiR-29a-5p alleviates astrocyte injury and regulates A1 and A2 astrocyte markers, glycogen synthase kinase 3 beta, and aquaporin 4 in astrocytes subjected to ischemia-reperfusion injury. Astrocytic miR-29a-5p may be a protective target for reducing HT and improving outcomes following mechanical reperfusion in acute ischemic stroke.
Authors
- Zhong‐Song Shi (ORCID: https://orcid.org/0000-0002-8169-757X)
- Chun Xiang
- Qian-Yu Chen
- Zhong-Run Huang
- Z.H. Liu (ORCID: https://orcid.org/0000-0002-9199-6493)
- Jin-Kun Zhuang
- Zexin Chen (ORCID: https://orcid.org/0000-0002-2685-4501)
- Chang-Luo Li
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Non-coding RNA Research
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.ncrna.2025.05.016
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Scientific and Technological Planning Project of Guangzhou City
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province