Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages
This study revealed promising new biomarkers for early detection of KC risk. Oxidative stress and cellular structural alterations seem to begin long before clinical signs and even before the biomechanical alterations can be detected with current clinical tools. Understanding how an initial imbalance of oxidative stress affects cellular mechanobiology is critical to developing new therapeutic strategies for the early treatment of KC.
Authors
- Carmen Pena (ORCID: https://orcid.org/0009-0001-2983-5277)
- Mercedes Conde‐Amboage (ORCID: https://orcid.org/0000-0003-0306-8142)
- Maite López‐López
- Susana B. Bravo (ORCID: https://orcid.org/0000-0001-7615-3079)
- Pablo Hervella (ORCID: https://orcid.org/0000-0003-1249-6333)
- Isabel Lema (ORCID: https://orcid.org/0000-0002-2894-0331)
- Uxía Regueiro (ORCID: https://orcid.org/0000-0001-9633-2701)
- Yaiza Pastoriza (ORCID: https://orcid.org/0009-0002-9928-018X)
Institutions
- Universidade de Santiago de Compostela (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1167/iovs.66.5.41
- Citations
- 2
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Banco Santander
- European Commission
- Axencia Galega de Innovación
- Xunta de Galicia
- Universidade de Santiago de Compostela
- Instituto de Salud Carlos III