<i>Clic6</i> Deficiency Triggers Aberrant Apical Microvilli in RPE
Clic6 deficiency induced aberrant RPE microvilli leading to a decreased intimacy between the RPE and photoreceptors and worsened the Crb1rd8 mutation phenotype that was inherent in C57BL/6N mice. CLIC6 may have a potential role in RPE dysfunction across species, including humans.
Authors
- Sara M. Thomasy (ORCID: https://orcid.org/0000-0001-5617-9677)
- Denise M. Imai (ORCID: https://orcid.org/0000-0003-0667-2054)
- Glenn Yiu (ORCID: https://orcid.org/0000-0003-3061-3310)
- Sangwan Park (ORCID: https://orcid.org/0000-0003-0381-0386)
- Brian C. Leonard (ORCID: https://orcid.org/0000-0003-2080-8480)
- K. C. Kent Lloyd (ORCID: https://orcid.org/0000-0002-5318-4144)
- Ala Moshiri (ORCID: https://orcid.org/0000-0002-4277-8094)
- Naran Suvarnpradip
- Niusha Kasiri
Institutions
- University of California, Davis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1167/iovs.66.5.44
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Eye Institute