Modest Effects of Age on Inflammatory Markers and Histological Features in the Murine Intervertebral Disc Injury Model
The intervertebral discs responded to injuries similarly, regardless of age. Because of the modest age-related differences in injury effects, using mice of the same age in experiments is essential, unless one aims to examine age-related differences. Given the costs of maintaining an aged mouse colony, the necessity of using old animals may need justification.
Authors
- Frances S. Shofer (ORCID: https://orcid.org/0000-0001-6813-4791)
- Zuozhen Tian
- Ling Qin (ORCID: https://orcid.org/0000-0002-2582-0078)
- Yejia Zhang (ORCID: https://orcid.org/0000-0002-7484-8800)
- Huan Wang (ORCID: https://orcid.org/0000-0003-1115-143X)
Institutions
- Hanalei Watershed Hui (US)
- Philadelphia VA Medical Center (US)
- Huazhong University of Science and Technology Hospital (CN)
- Huazhong University of Science and Technology (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- American Journal of Physical Medicine & Rehabilitation
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/phm.0000000000002773
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00