Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated <i>Clostridioides difficile</i> Infections, Canada, 2015–2022
We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult and pediatric patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015-2022. Of 30,824 reported CDI cases, 94.9% (29,250/30,824) were among adult (73.2% HA; 26.8% CA) and 5.1% (1,574/30,824) pediatric (77.6% HA; 22.4% CA) patients. During the study period, adult HA CDI rates decreased by 19.9% and CA CDI rates remained stable; pediatric HA CDI rates decreased by 29.6% and CA CDI decreased by 58.3%. Ribotype (RT) 106 was most common among both groups and replaced RT027 as the predominant strain type. RT027 was most associated with adult patients, HA acquisition, severe CDI, and severe outcomes. Moxifloxacin resistance was higher in adult than pediatric cases; clindamycin and rifampin resistance rates were similar between groups. Continued national surveillance is integral to understanding the epidemiology of adult and pediatric CDI in Canada and informing prevention efforts.
Authors
- Diane Lee (ORCID: https://orcid.org/0009-0001-4660-2109)
- Bonita E. Lee (ORCID: https://orcid.org/0000-0001-8510-237X)
- Pamela Kibsey
- Yves Longtin (ORCID: https://orcid.org/0000-0002-4532-379X)
- Meghan Engbretson (ORCID: https://orcid.org/0000-0003-2127-1021)
- Gerald A. Evans (ORCID: https://orcid.org/0000-0003-2557-0897)
- Dominik Mertz (ORCID: https://orcid.org/0000-0003-4337-1613)
- Blanda Chow
- George R. Golding (ORCID: https://orcid.org/0000-0002-4285-4747)
- Romeo Hizon
- Michelle Science (ORCID: https://orcid.org/0000-0002-2855-8570)
- Nicole D. Anderson (ORCID: https://orcid.org/0000-0002-5979-2220)
- Jocelyn A. Srigley (ORCID: https://orcid.org/0000-0002-0030-7665)
- Suzanne Bakai-Anderson
- Jeannette Comeau (ORCID: https://orcid.org/0000-0003-2132-674X)
- Jenine R. Leal (ORCID: https://orcid.org/0000-0002-0308-4890)
- Nisha Thampi (ORCID: https://orcid.org/0000-0003-0208-6277)
- Susy Hota (ORCID: https://orcid.org/0000-0002-3911-7033)
- Kathryn N. Suh (ORCID: https://orcid.org/0000-0002-8073-0243)
- Jessica Minion (ORCID: https://orcid.org/0000-0002-8863-5697)
- Kevin Katz
- Tim Du (ORCID: https://orcid.org/0000-0001-8037-2768)
- Anada Silva
- Jennie Johnstone (ORCID: https://orcid.org/0000-0002-3785-6617)
- Kristen Versluys
- Cassandra Lybeck (ORCID: https://orcid.org/0009-0007-5792-4246)
- Matthew Garrod (ORCID: https://orcid.org/0000-0003-4995-7949)
- Ian Davis (ORCID: https://orcid.org/0000-0002-4048-6856)
- Charles Frenette (ORCID: https://orcid.org/0000-0002-8996-0766)
- Alice Wong (ORCID: https://orcid.org/0000-0001-5760-0136)
- Elizabeth Oates
- Joanne M. Langley (ORCID: https://orcid.org/0000-0003-3270-7345)
- Kelly Baekyung Choi (ORCID: https://orcid.org/0000-0002-0204-1602)
- Reena Titoria
- Sean Ahmed
- Jenna Leamon
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-05-28
- DOI
- https://doi.org/10.3201/eid3106.250182
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00