Characteristics and Therapeutic Strategies for Diffuse Cutaneous Mastocytosis
In this cohort study, DCM presentation differs significantly from MPCM, with a higher risk of anaphylaxis and aggressive systemic forms, the latter being consistently associated with the KIT D816V variant. Tyrosine kinase inhibitors and sirolimus were generally effective and well tolerated in this pediatric population, with the choice of treatment depending on the type of KIT variants.
Authors
- S. Mallet (ORCID: https://orcid.org/0000-0003-2884-0645)
- Sylvie Fraitag (ORCID: https://orcid.org/0000-0002-2258-2051)
- Nicolas Garcelon (ORCID: https://orcid.org/0000-0002-3326-2811)
- Julien Rossignol (ORCID: https://orcid.org/0000-0003-3052-1424)
- N. Bellon (ORCID: https://orcid.org/0000-0003-3311-1674)
- Julie Agopian (ORCID: https://orcid.org/0000-0003-4094-6258)
- A.‐C. Bursztejn (ORCID: https://orcid.org/0000-0002-3281-7299)
- J. Bonigen (ORCID: https://orcid.org/0000-0001-5362-5694)
- Laura Polivka (ORCID: https://orcid.org/0000-0002-5142-6234)
- Philippe Drabent (ORCID: https://orcid.org/0000-0003-0273-0050)
- Michel Arock (ORCID: https://orcid.org/0000-0002-3990-4408)
- Alice Phan (ORCID: https://orcid.org/0000-0003-4246-5853)
- S. Barbarot (ORCID: https://orcid.org/0000-0002-6629-9100)
- Delphine Carré
- F. Skowron (ORCID: https://orcid.org/0000-0002-0564-6578)
- Patrice Dubreuil (ORCID: https://orcid.org/0000-0003-1155-1150)
- P. Vabres (ORCID: https://orcid.org/0000-0001-8693-3183)
- C. Méni (ORCID: https://orcid.org/0000-0003-2272-378X)
- Christine Bodemer (ORCID: https://orcid.org/0000-0001-8772-0905)
- Olivier Hermine (ORCID: https://orcid.org/0000-0003-2574-3874)
- A. Welfringer‐Morin (ORCID: https://orcid.org/0000-0001-7479-3689)
- Stéphane Barète (ORCID: https://orcid.org/0000-0003-1593-9750)
- H. Aubert (ORCID: https://orcid.org/0000-0003-1688-9900)
- Paula Pernea (ORCID: https://orcid.org/0009-0001-4863-0402)
- Anne-Claire Bing-Lecointe
- E. Puzenat
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hospices Civils de Lyon (FR)
- Association Francaise contre les Myopathies (FR)
- Pitié-Salpêtrière Hospital (FR)
- Groupe Hospitalier du Havre (FR)
- Centre Hospitalier Annecy Genevois (FR)
- Centre de Recherche en Cancérologie de Marseille (FR)
- Institut des Maladies Génétiques Imagine (FR)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1001/jamadermatol.2025.1488
- Citations
- 2
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 1.59