Organic cation transporter-3 mediates exogenous histamine uptake by primary mast cells
These findings suggest that OCT3 mediates exogenous histamine uptake by primary mast cells and that deficiency of OCT3 reduces intracellular histamine levels and downregulates IgE-mediated histamine release in mast cells.
Authors
- Yoshiaki Shinohara (ORCID: https://orcid.org/0000-0002-8975-4604)
- Kayoko Ishimaru (ORCID: https://orcid.org/0000-0002-6755-3203)
- Hiroaki Nagatomo
- Nguyen Quoc Vuong Tran (ORCID: https://orcid.org/0000-0003-4038-2704)
- Satoshi Tanaka (ORCID: https://orcid.org/0000-0002-3468-7694)
- Nobuhiro Nakano (ORCID: https://orcid.org/0000-0002-5317-5950)
- Keishi Narita (ORCID: https://orcid.org/0000-0002-7602-8523)
- Thuy-An Nguyen (ORCID: https://orcid.org/0009-0008-9607-6873)
- Yuki Nakamura (ORCID: https://orcid.org/0000-0003-4931-2489)
- Atsuhito Nakao (ORCID: https://orcid.org/0000-0002-4222-8922)
- Kentaro Yoshimura
- Yoshiaki Kobayashi
Institutions
- Iwate Medical University (JP)
- Kyoto Pharmaceutical University (JP)
- Juntendo University (JP)
- University of Yamanashi (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.jacig.2025.100499
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science