Whole-genome sequencing confirms Shigella flexneri infection in a child with shock and suspected multisystem inflammatory syndrome in children: A case report
This case underscores the importance of systematic microbiological workup in suspected systemic inflammatory syndromes, to identify infections that are treatable and of public health relevance. Given the rarity of <i>Shigella</i> septic shock in immunocompetent individuals, this case raises the possibility that recent SARS-CoV-2 infection led to immune dysregulation and exaggerated inflammatory responses to <i>Shigella</i>. It also demonstrates the utility of molecular testing for rapid diagnosis and confirmation of gastrointestinal infection.
Authors
- Andrew G. McArthur (ORCID: https://orcid.org/0000-0002-1142-3063)
- Sheridan J.C. Baker (ORCID: https://orcid.org/0009-0004-2240-525X)
- Laura K. Erdman (ORCID: https://orcid.org/0000-0001-8142-825X)
- Tania Cellucci (ORCID: https://orcid.org/0000-0002-6022-495X)
- Donald Brody Duncan (ORCID: https://orcid.org/0000-0002-7634-6484)
- Cheryl Main (ORCID: https://orcid.org/0000-0001-5216-0637)
- Jeffrey M. Pernica (ORCID: https://orcid.org/0000-0002-4380-5402)
- Marek Smieja (ORCID: https://orcid.org/0000-0003-1655-3761)
- Candy Rutherford
Institutions
- McMaster Children's Hospital (CA)
- Hamilton Regional Laboratory Medicine Program (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- IDCases
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.idcr.2025.e02274
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mitacs