Gut microbiota-derived phenylacetylglutamine mitigates neuroinflammation induced by intracerebral hemorrhage in mice
Gut microbiota-derived PAGIn played a crucially regulatory role in microglia-mediated neuroinflammation via β2AR after ICH. The supplementation of PAGIn following ICH in mice emerged as a potential therapeutic strategy to mitigate ICH-induced brain injury.
Authors
- Xiongjie Fu
- Qiuping Gu
- Yan Ma (ORCID: https://orcid.org/0000-0002-5242-1339)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0002-0431-5355)
- Linfeng Fan
- Haopu Lin
- Xuchao He
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108357
- Citations
- 4
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Natural Science Foundation of China
- Department of Education of Zhejiang Province
- Health Commission of Zhejiang Province