Integrating Magnetic Resonance Chemical Shift Imaging for Localized Prostate Cancer Risk Stratification on the Basis of the Impact of Periprostatic Brown Adipocytes Within Tumor Microenvironment
In the study, the chemical shift image of MRI in 21 localized patients with prostate cancer revealed higher periprostatic adipose tissue water-to-oil ratio among patients with high-risk prostate cancer. Adipokines within the tumor-microenvironment attribute to the cancer aggressiveness, and targeting the fat fraction signal in MRI could improve the current risk stratification strategy.
Authors
- Gia-Shing Shieh (ORCID: https://orcid.org/0000-0003-2480-4313)
- Wen-Der Lin
- Kuan‐Yu Wu (ORCID: https://orcid.org/0000-0002-0640-1505)
- Jhih-Kai Pan (ORCID: https://orcid.org/0000-0002-1244-283X)
- Hui‐Chuan Cheng
- Yung-Ming Kuo (ORCID: https://orcid.org/0009-0006-1169-7159)
- Che‐Yuan Hu (ORCID: https://orcid.org/0000-0001-5151-4552)
- Pei‐Jung Lu (ORCID: https://orcid.org/0000-0002-8143-5668)
- Chih-Yu Shen
Institutions
- National University of Tainan (TW)
- National Formosa University (TW)
- Chest Hospital, Ministry of Health and Welfare (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1245/s10434-025-17512-5
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33