TLR2 or TLR4 Stimulation Induces Transmembrane TNF-Driven Priming in Macrophages Which Results in Improved Clearance of a Subsequent Staphylococcus aureus Infection
Our results demonstrated that TNF produced in response to TLR stimulated BMDMs was required for improved clearance of a subsequent S. aureus infection. We found that sTNF did not contribute to this priming, which suggested that tmTNF may be critical for BMDM priming which leads to improved S. aureus clearance.
Authors
- Monica Hall (ORCID: https://orcid.org/0000-0002-4009-4617)
- Agnieszka Rynda‐Apple (ORCID: https://orcid.org/0000-0003-4333-9971)
- Alexis Alexandria Hatton
- Jasper L. Gattiker (ORCID: https://orcid.org/0000-0002-5579-8262)
- Diane Bimczok (ORCID: https://orcid.org/0000-0002-8817-7243)
- Kelly M. Shepardson (ORCID: https://orcid.org/0000-0003-3631-2594)
- Abby Luu
- Evelyn E. Benson
Institutions
- University of California, Merced (US)
- Montana State University (US)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1159/000546011
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- M.J. Murdock Charitable Trust
- Montana State University
- National Institutes of Health